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| Management number | 204569867 | Release Date | 2025/10/14 | List Price | $11.84 | Model Number | 204569867 | ||
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Comfortis Chewable Tablets are fast-acting, vet-prescribed oral flea treatments available in multiple weight-specific strengths for dogs (5–120 lbs) and cats (4.1–24 lbs). Powered by the active ingredient spinosad, each beef-flavored chewable starts killing fleas within 30 minutes and protects your pet for a full 30 days with a single monthly dose. Comfortis is convenient for multi-pet households, as it’s safe for both dogs and cats, and avoids the mess and residue of topical solutions. Prescription required.
|
Ingredient |
Purpose |
Source/Note |
|
Spinosad |
Kills adult fleas |
Derived from Saccharopolyspora spinosa (soil bacterium), neurotoxin specific to fleas |
|
Beef Flavor |
Enhance palatability |
Artificial flavor, not suitable for beef-allergic pets |
|
Inactive agents |
Chewable tablet formation |
Includes binders, starch, cellulose, flavorings, preservatives |
For administration to dogs and cats at least 14 weeks of age and above minimum weight listed.
Administer once monthly with food to maximize absorption and reduce vomiting risk.
|
Pet Type & Weight Range |
Spinosad per Tablet |
Tablets to Administer |
Variant Box Color / Use |
|
Dogs 5-10 lbs / Cats 4.1-6 lbs |
140 mg |
1 monthly |
Pink Box / Small pets |
|
Dogs 10.1-20 lbs / Cats 6.1-12 lbs |
270 mg |
1 monthly |
Orange Box / Small-medium |
|
Dogs 20.1-40 lbs / Cats 12.1-24 lbs |
560 mg |
1 monthly |
Green Box / Medium-large |
|
Dogs 40.1-60 lbs |
810 mg |
1 monthly |
Blue Box / Large |
|
Dogs 60.1-120 lbs |
1,620 mg* |
1 monthly |
Brown Box / X-Large |
*Note: Double 810 mg tablets may be used for dogs over 60 lbs (confirm with your vet).
Administer with a full meal.
Do not split tablets between pets.
If vomiting occurs within 1 hour, repeat the full dose.
Always treat all pets in the home for optimal flea control.
Never double-dose to compensate for a missed dose.
Not for use in pets under 14 weeks of age.
Do not use in pets with known allergies to spinosad.
Use caution in pets with seizure history; consult your vet.
Not evaluated for breeding, pregnant, or lactating females (ask your vet first).
Store between 68-77°F (20-25°C), away from moisture and light.
For animal use only; keep out of reach of children.
Store at 68-77°F (20-25°C).
Keep in original packaging, away from light and moisture.
Keep out of reach of children and household pets.
Rapid Action: Starts killing fleas in 30 minutes, full efficacy in 4 hours.
Full Month Coverage: One chewable provides 30 days of protection.
Breaks Flea Life Cycle: Eliminates adult fleas before they lay eggs.
No Mess: Oral formula leaves no residue or odor.
Palatable: Beef flavoring is generally well accepted by pets.
Waterproof: Bathing and swimming do not reduce effectiveness.
Safe for Combined Homes: Suitable for households with both cats and dogs.
Reduces Flea Allergy Dermatitis (FAD): Alleviates allergic reactions caused by fleas.
Vet-Recommended: FDA-approved and clinically tested.
Comfortis is for killing and preventing adult flea infestations in dogs and cats, offering rapid relief and month-long protection.
Generally yes (such as ivermectin-based products), but consult your vet before combining treatments.
No, it only targets adult fleas. Separate medication is needed for ticks, mites, or worms.
Yes, but use the correct weight- and species-specific variant. Never share one tablet between pets.
Administer the missed dose as soon as possible, then resume the regular schedule.
Yes, Comfortis requires a valid veterinary prescription.
Possible side effects include vomiting (most common), decreased appetite, lethargy, diarrhea, and – rarely –seizures. If your pet shows severe reactions, contact a veterinarian immediately.
Consult your veterinarian—safety in breeding or lactating animals has not been fully evaluated.
No. As an oral product, it remains effective even after bathing or swimming.
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